Drug interactions
Carbenoxolone + Carvedilol
Severity: Moderate
Carbenoxolone and Carvedilol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbenoxolone has mineralocorticoid-like activity that causes sodium and water retention, hypertension and potassium loss. These effects can counteract the blood pressure lowering of carvedilol and the hypokalemia may add to arrhythmia risk in cardiac patients.
What this interaction means in plain words
Carbenoxolone and Carvedilol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism through carbenoxolone-induced mineralocorticoid effects (fluid retention, hypokalemia) opposing antihypertensive action.
What to do
Monitor blood pressure, fluid status and serum potassium during combined use. Correct hypokalemia and consider an alternative to carbenoxolone if hypertension or edema develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Carbenoxolone and Carvedilol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Carvedilol
Frequently asked questions
Can I take Carbenoxolone with Carvedilol?
MediHelp rates the interaction as moderate. Carbenoxolone and Carvedilol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbenoxolone has mineralocorticoid-like activity that causes sodium and water retention, hypertension and potassium loss. These effects can counteract the blood pressure lowering of carvedilol and the hypokalemia may add to arrhythmia risk in cardiac patients.
How serious is the interaction between Carbenoxolone and Carvedilol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status and serum potassium during combined use. Correct hypokalemia and consider an alternative to carbenoxolone if hypertension or edema develops.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
