Drug interactions
Carbenoxolone + Epinephrine
Severity: Moderate
Carbenoxolone and Epinephrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbenoxolone has mineralocorticoid-like effects that cause potassium loss, and epinephrine drives potassium into cells. Combined use can deepen hypokalemia and increase the risk of arrhythmias.
What this interaction means in plain words
Carbenoxolone and Epinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mineralocorticoid-mediated renal potassium wasting plus beta2-mediated cellular potassium uptake.
What to do
Monitor serum potassium and correct deficits when epinephrine is given systemically. Consider ECG monitoring in patients with cardiac disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Carbenoxolone with Epinephrine?
MediHelp rates the interaction as moderate. Carbenoxolone and Epinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbenoxolone has mineralocorticoid-like effects that cause potassium loss, and epinephrine drives potassium into cells. Combined use can deepen hypokalemia and increase the risk of arrhythmias.
How serious is the interaction between Carbenoxolone and Epinephrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and correct deficits when epinephrine is given systemically. Consider ECG monitoring in patients with cardiac disease.
What other medicines interact with Epinephrine?
MediHelp also lists interactions of Epinephrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Epinephrine page.
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