Drug interactions
Carbenoxolone + Fenoprofen
Severity: Moderate
Carbenoxolone and Fenoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbenoxolone has mineralocorticoid-like effects causing sodium and water retention, hypokalemia and hypertension. Fenoprofen also promotes fluid retention and can raise blood pressure, so the two together may worsen edema, hypertension and heart failure. Hypokalemia from carbenoxolone may be partly offset by NSAID effects but the net result is unpredictable.
What this interaction means in plain words
Carbenoxolone and Fenoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive sodium and fluid retention from mineralocorticoid-like activity and NSAID inhibition of renal prostaglandins.
What to do
Monitor blood pressure, edema, serum potassium and renal function. Review the need for either drug in patients with heart failure or hypertension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Frequently asked questions
Can I take Carbenoxolone with Fenoprofen?
MediHelp rates the interaction as moderate. Carbenoxolone and Fenoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbenoxolone has mineralocorticoid-like effects causing sodium and water retention, hypokalemia and hypertension. Fenoprofen also promotes fluid retention and can raise blood pressure, so the two together may worsen edema, hypertension and heart failure. Hypokalemia from carbenoxolone may be partly offset by NSAID effects but the net result is unpredictable.
How serious is the interaction between Carbenoxolone and Fenoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, edema, serum potassium and renal function. Review the need for either drug in patients with heart failure or hypertension.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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