Drug interactions
Carbenoxolone + Ketorolac
Severity: Moderate
Carbenoxolone and Ketorolac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbenoxolone causes sodium and water retention with potassium loss and can raise blood pressure, and NSAIDs may add to fluid retention and renal stress. Ketorolac may also counteract the mucosal protective purpose of carbenoxolone in the GI tract.
What this interaction means in plain words
Carbenoxolone and Ketorolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Carbenoxolone has mineralocorticoid-like effects, and NSAID-related prostaglandin inhibition adds sodium retention and reduced renal perfusion.
What to do
Monitor blood pressure, edema, serum potassium and renal function. Prefer an alternative analgesic if fluid retention or hypokalemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Frequently asked questions
Can I take Carbenoxolone with Ketorolac?
MediHelp rates the interaction as moderate. Carbenoxolone and Ketorolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbenoxolone causes sodium and water retention with potassium loss and can raise blood pressure, and NSAIDs may add to fluid retention and renal stress. Ketorolac may also counteract the mucosal protective purpose of carbenoxolone in the GI tract.
How serious is the interaction between Carbenoxolone and Ketorolac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, edema, serum potassium and renal function. Prefer an alternative analgesic if fluid retention or hypokalemia develops.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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