Drug interactions
Carbenoxolone + Olmesartan
Severity: Moderate
Carbenoxolone and Olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbenoxolone has mineralocorticoid-like effects causing sodium and fluid retention, hypertension and hypokalemia. This can oppose olmesartan's blood pressure effect.
What this interaction means in plain words
Carbenoxolone and Olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Carbenoxolone inhibits 11-beta-hydroxysteroid dehydrogenase, producing mineralocorticoid excess that opposes ARB effects.
What to do
Monitor blood pressure, potassium and fluid status. Consider an alternative to carbenoxolone if blood pressure control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Frequently asked questions
Can I take Carbenoxolone with Olmesartan?
MediHelp rates the interaction as moderate. Carbenoxolone and Olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbenoxolone has mineralocorticoid-like effects causing sodium and fluid retention, hypertension and hypokalemia. This can oppose olmesartan's blood pressure effect.
How serious is the interaction between Carbenoxolone and Olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, potassium and fluid status. Consider an alternative to carbenoxolone if blood pressure control is lost.
What other medicines interact with Olmesartan?
MediHelp also lists interactions of Olmesartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Olmesartan page.
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