Drug interactions
Carbenoxolone + Telmisartan
Severity: Moderate
Carbenoxolone and Telmisartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbenoxolone has mineralocorticoid-like effects causing sodium and fluid retention, hypokalemia and hypertension. This can oppose telmisartan's antihypertensive effect, while potassium effects may partly offset each other.
What this interaction means in plain words
Carbenoxolone and Telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Carbenoxolone inhibits 11-beta-hydroxysteroid dehydrogenase, producing mineralocorticoid excess that opposes ARB-mediated effects.
What to do
Monitor blood pressure, serum potassium and fluid status. Consider stopping carbenoxolone if hypertension or edema develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telmisartan
- Aliskiren + Telmisartan Contraindicated
- Sparsentan + Telmisartan Contraindicated
- Amifostine + Telmisartan Major
- Amiloride + Telmisartan Major
- Amlodipine-benazepril + Telmisartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Telmisartan Major
Frequently asked questions
Can I take Carbenoxolone with Telmisartan?
MediHelp rates the interaction as moderate. Carbenoxolone and Telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbenoxolone has mineralocorticoid-like effects causing sodium and fluid retention, hypokalemia and hypertension. This can oppose telmisartan's antihypertensive effect, while potassium effects may partly offset each other.
How serious is the interaction between Carbenoxolone and Telmisartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum potassium and fluid status. Consider stopping carbenoxolone if hypertension or edema develops.
What other medicines interact with Telmisartan?
MediHelp also lists interactions of Telmisartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan page.
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