Drug interactions
Carbidopa-entacapone-levodopa + Clonidine
Severity: Moderate
Carbidopa-entacapone-levodopa and Clonidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levodopa can cause orthostatic hypotension, and clonidine lowers blood pressure by central sympatholytic action. Together they may produce additive hypotension and sedation.
What this interaction means in plain words
Carbidopa-entacapone-levodopa and Clonidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbidopa-entacapone-levodopa belongs to Central Nervous System; Clonidine belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic hypotensive effects of dopaminergic stimulation and central alpha-2 agonism.
What to do
Monitor blood pressure including orthostatic readings when levodopa is started or adjusted. Reduce the clonidine dose if hypotension develops, and avoid abrupt clonidine withdrawal.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicated
- Carbidopa-entacapone-levodopa + Phenelzine Contraindicated
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-entacapone-levodopa Major
- Asenapine transdermal + Carbidopa-entacapone-levodopa Major
Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Frequently asked questions
Can I take Carbidopa-entacapone-levodopa with Clonidine?
MediHelp rates the interaction as moderate. Carbidopa-entacapone-levodopa and Clonidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levodopa can cause orthostatic hypotension, and clonidine lowers blood pressure by central sympatholytic action. Together they may produce additive hypotension and sedation.
How serious is the interaction between Carbidopa-entacapone-levodopa and Clonidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure including orthostatic readings when levodopa is started or adjusted. Reduce the clonidine dose if hypotension develops, and avoid abrupt clonidine withdrawal.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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