Drug interactions
Carbidopa-entacapone-levodopa + Cyclopenthiazide
Severity: Moderate
Carbidopa-entacapone-levodopa and Cyclopenthiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levodopa can cause orthostatic hypotension, and thiazide diuretics lower blood pressure through volume depletion. Together they may increase the risk of dizziness, falls and symptomatic hypotension, especially in older patients.
What this interaction means in plain words
Carbidopa-entacapone-levodopa and Cyclopenthiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effects: levodopa-related vasodilation and autonomic effects combined with diuretic-induced volume and sodium loss.
What to do
Check blood pressure including standing readings when starting or adjusting either drug, and reduce the diuretic dose if orthostatic symptoms develop. Maintain adequate hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicated
- Carbidopa-entacapone-levodopa + Phenelzine Contraindicated
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-entacapone-levodopa Major
- Asenapine transdermal + Carbidopa-entacapone-levodopa Major
Frequently asked questions
Can I take Carbidopa-entacapone-levodopa with Cyclopenthiazide?
MediHelp rates the interaction as moderate. Carbidopa-entacapone-levodopa and Cyclopenthiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levodopa can cause orthostatic hypotension, and thiazide diuretics lower blood pressure through volume depletion. Together they may increase the risk of dizziness, falls and symptomatic hypotension, especially in older patients.
How serious is the interaction between Carbidopa-entacapone-levodopa and Cyclopenthiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood pressure including standing readings when starting or adjusting either drug, and reduce the diuretic dose if orthostatic symptoms develop. Maintain adequate hydration.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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