Drug interactions
Carbidopa-entacapone-levodopa + Doxazosin
Severity: Moderate
Carbidopa-entacapone-levodopa and Doxazosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levodopa can cause orthostatic hypotension, and doxazosin blocks alpha-1 receptors, which can also cause marked postural hypotension. Combined use increases the risk of dizziness, syncope and falls.
What this interaction means in plain words
Carbidopa-entacapone-levodopa and Doxazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbidopa-entacapone-levodopa belongs to Central Nervous System; Doxazosin belongs to Genitourinary.
Why it happens
Additive pharmacodynamic hypotensive effects of dopaminergic stimulation and alpha-1 blockade.
What to do
Monitor orthostatic blood pressure when levodopa is started or adjusted. Give doxazosin at bedtime and reduce its dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicated
- Carbidopa-entacapone-levodopa + Phenelzine Contraindicated
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-entacapone-levodopa Major
- Asenapine transdermal + Carbidopa-entacapone-levodopa Major
Other interactions of Doxazosin
- Alfuzosin + Doxazosin Major
- Amifostine + Doxazosin Major
- Avanafil + Doxazosin Major
- Doxazosin + Dutasteride-tamsulosin Major
- Doxazosin + Phentolamine Major
- Doxazosin + Prazosin Major
Frequently asked questions
Can I take Carbidopa-entacapone-levodopa with Doxazosin?
MediHelp rates the interaction as moderate. Carbidopa-entacapone-levodopa and Doxazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levodopa can cause orthostatic hypotension, and doxazosin blocks alpha-1 receptors, which can also cause marked postural hypotension. Combined use increases the risk of dizziness, syncope and falls.
How serious is the interaction between Carbidopa-entacapone-levodopa and Doxazosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor orthostatic blood pressure when levodopa is started or adjusted. Give doxazosin at bedtime and reduce its dose if symptomatic hypotension occurs.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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