Drug interactions
Carbidopa-entacapone-levodopa + Fenoldopam
Severity: Moderate
Carbidopa-entacapone-levodopa and Fenoldopam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenoldopam is a dopamine D1 agonist that lowers blood pressure through vasodilation. Levodopa converted to dopamine and levodopa-related orthostatic hypotension may add to this effect, and dopamine antagonistic or agonistic overlap may alter response.
What this interaction means in plain words
Carbidopa-entacapone-levodopa and Fenoldopam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effects through dopaminergic vasodilation and reduced sympathetic tone.
What to do
Monitor blood pressure continuously during fenoldopam infusion and titrate cautiously. Reduce the infusion rate if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicated
- Carbidopa-entacapone-levodopa + Phenelzine Contraindicated
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-entacapone-levodopa Major
- Asenapine transdermal + Carbidopa-entacapone-levodopa Major
Frequently asked questions
Can I take Carbidopa-entacapone-levodopa with Fenoldopam?
MediHelp rates the interaction as moderate. Carbidopa-entacapone-levodopa and Fenoldopam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenoldopam is a dopamine D1 agonist that lowers blood pressure through vasodilation. Levodopa converted to dopamine and levodopa-related orthostatic hypotension may add to this effect, and dopamine antagonistic or agonistic overlap may alter response.
How serious is the interaction between Carbidopa-entacapone-levodopa and Fenoldopam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure continuously during fenoldopam infusion and titrate cautiously. Reduce the infusion rate if hypotension develops.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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