Drug interactions
Carbidopa-entacapone-levodopa + Fentanyl iontophoretic transdermal system
Severity: Moderate
Carbidopa-entacapone-levodopa and Fentanyl iontophoretic transdermal system: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fentanyl causes sedation and respiratory depression, and levodopa-containing products can cause drowsiness and dizziness. The combination may increase sedation and impair psychomotor performance, and opioids can also worsen orthostatic hypotension.
What this interaction means in plain words
Carbidopa-entacapone-levodopa and Fentanyl iontophoretic transdermal system can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant and hypotensive effects; no significant pharmacokinetic interaction is established.
What to do
Monitor for excessive sedation, respiratory depression and orthostatic hypotension. Counsel patients on fall risk and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicated
- Carbidopa-entacapone-levodopa + Phenelzine Contraindicated
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-entacapone-levodopa Major
- Asenapine transdermal + Carbidopa-entacapone-levodopa Major
Frequently asked questions
Can I take Carbidopa-entacapone-levodopa with Fentanyl iontophoretic transdermal system?
MediHelp rates the interaction as moderate. Carbidopa-entacapone-levodopa and Fentanyl iontophoretic transdermal system can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fentanyl causes sedation and respiratory depression, and levodopa-containing products can cause drowsiness and dizziness. The combination may increase sedation and impair psychomotor performance, and opioids can also worsen orthostatic hypotension.
How serious is the interaction between Carbidopa-entacapone-levodopa and Fentanyl iontophoretic transdermal system?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation, respiratory depression and orthostatic hypotension. Counsel patients on fall risk and driving.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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