Drug interactions
Carbidopa-entacapone-levodopa + Isradipine
Severity: Moderate
Carbidopa-entacapone-levodopa and Isradipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levodopa can cause orthostatic hypotension, and isradipine lowers blood pressure through vasodilation. Used together, the hypotensive effect may be greater, with dizziness or falls, especially when levodopa is started or increased.
What this interaction means in plain words
Carbidopa-entacapone-levodopa and Isradipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic blood pressure lowering from levodopa-related orthostatic hypotension and calcium channel blocker vasodilation.
What to do
Monitor supine and standing blood pressure when levodopa therapy is started or adjusted. Reduce the isradipine dose if symptomatic hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicated
- Carbidopa-entacapone-levodopa + Phenelzine Contraindicated
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-entacapone-levodopa Major
- Asenapine transdermal + Carbidopa-entacapone-levodopa Major
Frequently asked questions
Can I take Carbidopa-entacapone-levodopa with Isradipine?
MediHelp rates the interaction as moderate. Carbidopa-entacapone-levodopa and Isradipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levodopa can cause orthostatic hypotension, and isradipine lowers blood pressure through vasodilation. Used together, the hypotensive effect may be greater, with dizziness or falls, especially when levodopa is started or increased.
How serious is the interaction between Carbidopa-entacapone-levodopa and Isradipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor supine and standing blood pressure when levodopa therapy is started or adjusted. Reduce the isradipine dose if symptomatic hypotension develops.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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