Drug interactions
Carbidopa-entacapone-levodopa + Ketanserin
Severity: Moderate
Carbidopa-entacapone-levodopa and Ketanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levodopa commonly causes orthostatic hypotension, and ketanserin has alpha-1 blocking antihypertensive activity. Combined use may produce additive hypotension, dizziness, or syncope.
What this interaction means in plain words
Carbidopa-entacapone-levodopa and Ketanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic hypotensive effects of levodopa and alpha-1 adrenergic blockade by ketanserin.
What to do
Monitor blood pressure, including orthostatic readings, when starting or titrating either drug. Lower the ketanserin dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicated
- Carbidopa-entacapone-levodopa + Phenelzine Contraindicated
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-entacapone-levodopa Major
- Asenapine transdermal + Carbidopa-entacapone-levodopa Major
Frequently asked questions
Can I take Carbidopa-entacapone-levodopa with Ketanserin?
MediHelp rates the interaction as moderate. Carbidopa-entacapone-levodopa and Ketanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levodopa commonly causes orthostatic hypotension, and ketanserin has alpha-1 blocking antihypertensive activity. Combined use may produce additive hypotension, dizziness, or syncope.
How serious is the interaction between Carbidopa-entacapone-levodopa and Ketanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, including orthostatic readings, when starting or titrating either drug. Lower the ketanserin dose if hypotension occurs.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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