Drug interactions
Carbidopa-entacapone-levodopa + Midazolam intranasal
Severity: Moderate
Carbidopa-entacapone-levodopa and Midazolam intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midazolam causes CNS and respiratory depression, and levodopa can add sedation and somnolence, including sudden sleep onset. Combined use may deepen sedation and impair breathing and alertness.
What this interaction means in plain words
Carbidopa-entacapone-levodopa and Midazolam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects of benzodiazepine GABA-A potentiation and levodopa-related somnolence.
What to do
Monitor sedation level, respiratory rate and oxygen saturation after intranasal midazolam, and avoid repeat dosing until the effects are assessed. Warn patients against driving or operating machinery afterward.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicated
- Carbidopa-entacapone-levodopa + Phenelzine Contraindicated
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-entacapone-levodopa Major
- Asenapine transdermal + Carbidopa-entacapone-levodopa Major
Frequently asked questions
Can I take Carbidopa-entacapone-levodopa with Midazolam intranasal?
MediHelp rates the interaction as moderate. Carbidopa-entacapone-levodopa and Midazolam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Midazolam causes CNS and respiratory depression, and levodopa can add sedation and somnolence, including sudden sleep onset. Combined use may deepen sedation and impair breathing and alertness.
How serious is the interaction between Carbidopa-entacapone-levodopa and Midazolam intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level, respiratory rate and oxygen saturation after intranasal midazolam, and avoid repeat dosing until the effects are assessed. Warn patients against driving or operating machinery afterward.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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