Drug interactions
Carbidopa-entacapone-levodopa + Olopatadine intranasal
Severity: Minor
Carbidopa-entacapone-levodopa and Olopatadine intranasal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olopatadine nasal spray can cause somnolence, and levodopa and entacapone can also cause drowsiness and sudden sleep onset. Together they may increase daytime impairment and psychomotor slowing.
What this interaction means in plain words
Carbidopa-entacapone-levodopa and Olopatadine intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive central nervous system sedative effects.
What to do
Counsel patients about drowsiness and avoid driving if sedated. Consider a less sedating alternative if somnolence occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicated
- Carbidopa-entacapone-levodopa + Phenelzine Contraindicated
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-entacapone-levodopa Major
- Asenapine transdermal + Carbidopa-entacapone-levodopa Major
Frequently asked questions
Can I take Carbidopa-entacapone-levodopa with Olopatadine intranasal?
MediHelp rates the interaction as minor. Carbidopa-entacapone-levodopa and Olopatadine intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Olopatadine nasal spray can cause somnolence, and levodopa and entacapone can also cause drowsiness and sudden sleep onset. Together they may increase daytime impairment and psychomotor slowing.
How serious is the interaction between Carbidopa-entacapone-levodopa and Olopatadine intranasal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about drowsiness and avoid driving if sedated. Consider a less sedating alternative if somnolence occurs.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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