Drug interactions
Carbidopa-entacapone-levodopa + Pimozide
Severity: Major
Carbidopa-entacapone-levodopa and Pimozide: major interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pimozide is a strong dopamine antagonist that opposes the effect of levodopa and may worsen parkinsonian symptoms. Pimozide also prolongs the QT interval, which adds concern.
What this interaction means in plain words
Carbidopa-entacapone-levodopa and Pimozide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carbidopa-entacapone-levodopa belongs to Central Nervous System; Pimozide belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism via D2 receptor blockade.
What to do
Avoid the combination and select an alternative with less dopamine blockade. If unavoidable, monitor motor function and ECG.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicated
- Carbidopa-entacapone-levodopa + Phenelzine Contraindicated
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-entacapone-levodopa Major
- Asenapine transdermal + Carbidopa-entacapone-levodopa Major
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Carbidopa-entacapone-levodopa with Pimozide?
MediHelp rates the interaction as major. Carbidopa-entacapone-levodopa and Pimozide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pimozide is a strong dopamine antagonist that opposes the effect of levodopa and may worsen parkinsonian symptoms. Pimozide also prolongs the QT interval, which adds concern.
How serious is the interaction between Carbidopa-entacapone-levodopa and Pimozide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and select an alternative with less dopamine blockade. If unavoidable, monitor motor function and ECG.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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