Drug interactions
Carbidopa-entacapone-levodopa + Polysaccharide iron
Severity: Moderate
Carbidopa-entacapone-levodopa and Polysaccharide iron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral iron can bind levodopa and entacapone in the gut, forming chelates that reduce absorption. This may lower levodopa exposure and weaken control of Parkinson symptoms.
What this interaction means in plain words
Carbidopa-entacapone-levodopa and Polysaccharide iron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chelation of levodopa and entacapone by iron in the gastrointestinal tract, reducing absorption.
What to do
Separate oral iron from levodopa products by at least 2 hours. Monitor motor response if iron is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicated
- Carbidopa-entacapone-levodopa + Phenelzine Contraindicated
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-entacapone-levodopa Major
- Asenapine transdermal + Carbidopa-entacapone-levodopa Major
Frequently asked questions
Can I take Carbidopa-entacapone-levodopa with Polysaccharide iron?
MediHelp rates the interaction as moderate. Carbidopa-entacapone-levodopa and Polysaccharide iron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral iron can bind levodopa and entacapone in the gut, forming chelates that reduce absorption. This may lower levodopa exposure and weaken control of Parkinson symptoms.
How serious is the interaction between Carbidopa-entacapone-levodopa and Polysaccharide iron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate oral iron from levodopa products by at least 2 hours. Monitor motor response if iron is started or stopped.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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