Drug interactions
Carboplatin + Dengue vaccine
Severity: Major
Carboplatin and Dengue vaccine: major interaction.
Last updated Sources: Base de donnees publique des medicaments (France)
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dengue vaccine is a live attenuated vaccine, and myelosuppressive chemotherapy may impair the immune response to it. There is also a theoretical risk of vaccine-related infection in an immunocompromised patient.
What this interaction means in plain words
Carboplatin and Dengue vaccine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Chemotherapy-induced immunosuppression reduces vaccine immunogenicity and may permit replication of the live virus.
What to do
Avoid giving the live dengue vaccine during chemotherapy. Defer vaccination until immune recovery, as recommended by the product labeling and oncology guidance.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Carboplatin
Frequently asked questions
Can I take Carboplatin with Dengue vaccine?
MediHelp rates the interaction as major. Carboplatin and Dengue vaccine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dengue vaccine is a live attenuated vaccine, and myelosuppressive chemotherapy may impair the immune response to it. There is also a theoretical risk of vaccine-related infection in an immunocompromised patient.
How serious is the interaction between Carboplatin and Dengue vaccine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving the live dengue vaccine during chemotherapy. Defer vaccination until immune recovery, as recommended by the product labeling and oncology guidance.
What other medicines interact with Carboplatin?
MediHelp also lists interactions of Carboplatin with, for example, Adenovirus types 4 and 7 live, Amikacin, Amphotericin b deoxycholate. The full list is on the Carboplatin page.
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