Drug interactions
Carboplatin + Elvitegravir / cobicistat / emtricitabine / tenofovir df
Severity: Moderate
Carboplatin and Elvitegravir / cobicistat / emtricitabine / tenofovir df: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenofovir disoproxil and cobicistat can affect renal tubular function and creatinine handling, while carboplatin is also renally toxic and renally cleared. Combined use may increase the risk of kidney injury and, with reduced clearance, greater carboplatin toxicity.
What this interaction means in plain words
Carboplatin and Elvitegravir / cobicistat / emtricitabine / tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity affecting the proximal tubule, with reduced renal elimination of renally cleared drugs.
What to do
Monitor serum creatinine, phosphate and electrolytes regularly, and dose carboplatin on current renal function. Consider an antiretroviral regimen with less renal toxicity if function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carboplatin
Frequently asked questions
Can I take Carboplatin with Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates the interaction as moderate. Carboplatin and Elvitegravir / cobicistat / emtricitabine / tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tenofovir disoproxil and cobicistat can affect renal tubular function and creatinine handling, while carboplatin is also renally toxic and renally cleared. Combined use may increase the risk of kidney injury and, with reduced clearance, greater carboplatin toxicity.
How serious is the interaction between Carboplatin and Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, phosphate and electrolytes regularly, and dose carboplatin on current renal function. Consider an antiretroviral regimen with less renal toxicity if function declines.
What other medicines interact with Carboplatin?
MediHelp also lists interactions of Carboplatin with, for example, Adenovirus types 4 and 7 live, Amikacin, Amphotericin b deoxycholate. The full list is on the Carboplatin page.
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