Drug interactions
Carboplatin + Ioversol
Severity: Moderate
Carboplatin and Ioversol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both carboplatin and iodinated contrast agents can injure the kidney, and carboplatin is renally cleared, so reduced renal function raises its exposure and myelosuppression. Contrast-induced nephropathy may therefore increase carboplatin toxicity. The risk is higher with pre-existing renal impairment or dehydration.
What this interaction means in plain words
Carboplatin and Ioversol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity, with reduced renal clearance of carboplatin.
What to do
Hydrate the patient and check serum creatinine before and after contrast. Recalculate the carboplatin dose from current renal function and monitor blood counts.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Carboplatin and Ioversol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Carboplatin
Frequently asked questions
Can I take Carboplatin with Ioversol?
MediHelp rates the interaction as moderate. Carboplatin and Ioversol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both carboplatin and iodinated contrast agents can injure the kidney, and carboplatin is renally cleared, so reduced renal function raises its exposure and myelosuppression. Contrast-induced nephropathy may therefore increase carboplatin toxicity. The risk is higher with pre-existing renal impairment or dehydration.
How serious is the interaction between Carboplatin and Ioversol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hydrate the patient and check serum creatinine before and after contrast. Recalculate the carboplatin dose from current renal function and monitor blood counts.
What other medicines interact with Carboplatin?
MediHelp also lists interactions of Carboplatin with, for example, Adenovirus types 4 and 7 live, Amikacin, Amphotericin b deoxycholate. The full list is on the Carboplatin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
