Drug interactions
Carboplatin + Methotrexate
Severity: Moderate
Carboplatin and Methotrexate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can harm the kidneys, and carboplatin may also cause myelosuppression and ototoxicity. Impaired renal function reduces methotrexate elimination and can sharply increase systemic toxicity.
What this interaction means in plain words
Carboplatin and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carboplatin belongs to Oncology; Methotrexate belongs to Oncology.
Why it happens
Additive nephrotoxicity and myelosuppression, with reduced renal function secondarily delaying methotrexate clearance.
What to do
Monitor serum creatinine, electrolytes and blood counts before and during treatment. Hydrate adequately and reduce or hold methotrexate if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Other interactions of Carboplatin
Frequently asked questions
Can I take Carboplatin with Methotrexate?
MediHelp rates the interaction as moderate. Carboplatin and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can harm the kidneys, and carboplatin may also cause myelosuppression and ototoxicity. Impaired renal function reduces methotrexate elimination and can sharply increase systemic toxicity.
How serious is the interaction between Carboplatin and Methotrexate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, electrolytes and blood counts before and during treatment. Hydrate adequately and reduce or hold methotrexate if renal function declines.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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