Drug interactions
Carboplatin + Olaparib
Severity: Major
Carboplatin and Olaparib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olaparib commonly causes anemia, neutropenia and thrombocytopenia, and carboplatin adds substantial bone marrow toxicity. Combining them can produce more frequent and prolonged cytopenias that often require dose modification.
What this interaction means in plain words
Carboplatin and Olaparib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carboplatin belongs to Oncology; Olaparib belongs to Oncology.
Why it happens
Additive myelosuppression from a PARP inhibitor and a DNA-damaging platinum agent.
What to do
Monitor complete blood counts frequently, especially early in treatment, and interrupt or reduce doses for significant cytopenias. Use supportive care such as transfusions or growth factors when needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Carboplatin
Other interactions of Olaparib
- Amiodarone + Olaparib Major
- Amobarbital + Olaparib Major
- Apalutamide + Olaparib Major
- Aprepitant + Olaparib Major
- Azathioprine + Olaparib Major
- Carbamazepine + Olaparib Major
Frequently asked questions
Can I take Carboplatin with Olaparib?
MediHelp rates the interaction as major. Carboplatin and Olaparib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Olaparib commonly causes anemia, neutropenia and thrombocytopenia, and carboplatin adds substantial bone marrow toxicity. Combining them can produce more frequent and prolonged cytopenias that often require dose modification.
How serious is the interaction between Carboplatin and Olaparib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts frequently, especially early in treatment, and interrupt or reduce doses for significant cytopenias. Use supportive care such as transfusions or growth factors when needed.
What other medicines interact with Carboplatin?
MediHelp also lists interactions of Carboplatin with, for example, Adenovirus types 4 and 7 live, Amikacin, Amphotericin b deoxycholate. The full list is on the Carboplatin page.
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