Drug interactions
Carboplatin + Tenofovir df
Severity: Moderate
Carboplatin and Tenofovir df: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenofovir disoproxil is eliminated renally and can cause proximal tubular toxicity. Carboplatin is also renally cleared and can impair renal function, so together they may worsen kidney function and raise tenofovir exposure.
What this interaction means in plain words
Carboplatin and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity with reduced renal clearance of tenofovir when kidney function declines.
What to do
Monitor serum creatinine, phosphate and estimated GFR during carboplatin cycles. Adjust tenofovir dosing or switch to an alternative antiretroviral if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Carboplatin and Tenofovir df, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Carboplatin
Frequently asked questions
Can I take Carboplatin with Tenofovir df?
MediHelp rates the interaction as moderate. Carboplatin and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tenofovir disoproxil is eliminated renally and can cause proximal tubular toxicity. Carboplatin is also renally cleared and can impair renal function, so together they may worsen kidney function and raise tenofovir exposure.
How serious is the interaction between Carboplatin and Tenofovir df?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, phosphate and estimated GFR during carboplatin cycles. Adjust tenofovir dosing or switch to an alternative antiretroviral if renal function declines.
What other medicines interact with Carboplatin?
MediHelp also lists interactions of Carboplatin with, for example, Adenovirus types 4 and 7 live, Amikacin, Amphotericin b deoxycholate. The full list is on the Carboplatin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
