Drug interactions
Carboplatin + Tenofovir disoproxil
Severity: Moderate
Carboplatin and Tenofovir disoproxil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can damage the kidney, and concurrent use may increase the likelihood of renal dysfunction. Decreased renal function can raise tenofovir exposure, and carboplatin is also renally cleared, which increases myelosuppression risk. Carboplatin is less nephrotoxic than cisplatin.
What this interaction means in plain words
Carboplatin and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity with reduced renal clearance of both drugs.
What to do
Monitor serum creatinine, phosphate and electrolytes before each carboplatin cycle. Dose-adjust tenofovir for renal function or switch to tenofovir alafenamide or another agent if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carboplatin
Frequently asked questions
Can I take Carboplatin with Tenofovir disoproxil?
MediHelp rates the interaction as moderate. Carboplatin and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can damage the kidney, and concurrent use may increase the likelihood of renal dysfunction. Decreased renal function can raise tenofovir exposure, and carboplatin is also renally cleared, which increases myelosuppression risk. Carboplatin is less nephrotoxic than cisplatin.
How serious is the interaction between Carboplatin and Tenofovir disoproxil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, phosphate and electrolytes before each carboplatin cycle. Dose-adjust tenofovir for renal function or switch to tenofovir alafenamide or another agent if renal function declines.
What other medicines interact with Carboplatin?
MediHelp also lists interactions of Carboplatin with, for example, Adenovirus types 4 and 7 live, Amikacin, Amphotericin b deoxycholate. The full list is on the Carboplatin page.
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