Drug interactions
Carisoprodol + Dextromoramide
Severity: Major
Carisoprodol and Dextromoramide: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dextromoramide is a potent opioid analgesic, and with carisoprodol it produces additive CNS and respiratory depression. This can lead to profound sedation, coma and death.
What this interaction means in plain words
Carisoprodol and Dextromoramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression.
What to do
Avoid the combination if possible; otherwise use the lowest effective doses and monitor sedation and respiratory rate closely. Counsel on overdose warning signs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Carisoprodol
Frequently asked questions
Can I take Carisoprodol with Dextromoramide?
MediHelp rates the interaction as major. Carisoprodol and Dextromoramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dextromoramide is a potent opioid analgesic, and with carisoprodol it produces additive CNS and respiratory depression. This can lead to profound sedation, coma and death.
How serious is the interaction between Carisoprodol and Dextromoramide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; otherwise use the lowest effective doses and monitor sedation and respiratory rate closely. Counsel on overdose warning signs.
What other medicines interact with Carisoprodol?
MediHelp also lists interactions of Carisoprodol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Carisoprodol page.
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