Drug interactions
Carisoprodol + Flurazepam
Severity: Major
Carisoprodol and Flurazepam: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carisoprodol combined with flurazepam increases sedation, next-day impairment and respiratory depression risk. Flurazepam's long-acting active metabolites can prolong the overlap, particularly in older adults.
What this interaction means in plain words
Carisoprodol and Flurazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS depression via GABA-A receptor modulation by benzodiazepine and meprobamate.
What to do
Avoid combined use where possible, especially in older adults. If necessary, use the lowest doses and monitor for oversedation and falls.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Carisoprodol
Frequently asked questions
Can I take Carisoprodol with Flurazepam?
MediHelp rates the interaction as major. Carisoprodol and Flurazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carisoprodol combined with flurazepam increases sedation, next-day impairment and respiratory depression risk. Flurazepam's long-acting active metabolites can prolong the overlap, particularly in older adults.
How serious is the interaction between Carisoprodol and Flurazepam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combined use where possible, especially in older adults. If necessary, use the lowest doses and monitor for oversedation and falls.
What other medicines interact with Carisoprodol?
MediHelp also lists interactions of Carisoprodol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Carisoprodol page.
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