Drug interactions
Carisoprodol + Levorphanol
Severity: Major
Carisoprodol and Levorphanol: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levorphanol is a potent opioid, and carisoprodol increases the risk of profound sedation, respiratory depression, coma and death. The combination is also associated with misuse.
What this interaction means in plain words
Carisoprodol and Levorphanol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression from opioid receptor agonism and GABA-A-mediated sedation from meprobamate.
What to do
Avoid if possible, or use the lowest effective doses and shortest duration. Monitor sedation and respiratory rate, and consider naloxone availability.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Carisoprodol
Frequently asked questions
Can I take Carisoprodol with Levorphanol?
MediHelp rates the interaction as major. Carisoprodol and Levorphanol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Levorphanol is a potent opioid, and carisoprodol increases the risk of profound sedation, respiratory depression, coma and death. The combination is also associated with misuse.
How serious is the interaction between Carisoprodol and Levorphanol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible, or use the lowest effective doses and shortest duration. Monitor sedation and respiratory rate, and consider naloxone availability.
What other medicines interact with Carisoprodol?
MediHelp also lists interactions of Carisoprodol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Carisoprodol page.
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