Drug interactions
Carvedilol + Darifenacin
Severity: Minor
Carvedilol and Darifenacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carvedilol is partly metabolized by CYP2D6, which darifenacin inhibits modestly. Carvedilol exposure may increase, causing more hypotension or bradycardia.
What this interaction means in plain words
Carvedilol and Darifenacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carvedilol belongs to Cardiovascular; Darifenacin belongs to Genitourinary.
Why it happens
CYP2D6 inhibition by darifenacin reduces carvedilol clearance.
What to do
Monitor blood pressure and heart rate when starting or stopping darifenacin. Adjust carvedilol dose only if symptomatic.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Darifenacin
Other interactions of Carvedilol
Frequently asked questions
Can I take Carvedilol with Darifenacin?
MediHelp rates the interaction as minor. Carvedilol and Darifenacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Carvedilol is partly metabolized by CYP2D6, which darifenacin inhibits modestly. Carvedilol exposure may increase, causing more hypotension or bradycardia.
How serious is the interaction between Carvedilol and Darifenacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or stopping darifenacin. Adjust carvedilol dose only if symptomatic.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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