Drug interactions
Carvedilol + Diphenhydramine
Severity: Minor
Carvedilol and Diphenhydramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diphenhydramine inhibits CYP2D6 and might raise carvedilol concentrations. The clinical effect with occasional use is likely small.
What this interaction means in plain words
Carvedilol and Diphenhydramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carvedilol belongs to Cardiovascular; Diphenhydramine belongs to Respiratory.
Why it happens
Diphenhydramine inhibition of CYP2D6-mediated carvedilol metabolism.
What to do
Monitor heart rate and blood pressure if diphenhydramine is used regularly, and reduce the carvedilol dose for symptomatic bradycardia or hypotension.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Carvedilol
Other interactions of Diphenhydramine
Frequently asked questions
Can I take Carvedilol with Diphenhydramine?
MediHelp rates the interaction as minor. Carvedilol and Diphenhydramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Diphenhydramine inhibits CYP2D6 and might raise carvedilol concentrations. The clinical effect with occasional use is likely small.
How serious is the interaction between Carvedilol and Diphenhydramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure if diphenhydramine is used regularly, and reduce the carvedilol dose for symptomatic bradycardia or hypotension.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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