Drug interactions
Carvedilol + Doxazosin
Severity: Moderate
Carvedilol and Doxazosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs block alpha-1 receptors, and carvedilol also blocks beta receptors, so combined use can cause marked hypotension. Dizziness, syncope and first-dose orthostatic effects are the main concerns.
What this interaction means in plain words
Carvedilol and Doxazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Doxazosin belongs to Genitourinary.
Why it happens
Additive alpha-1 adrenergic blockade, plus beta blockade from carvedilol.
What to do
Introduce one agent at a time at low doses and titrate slowly. Monitor orthostatic blood pressure and reduce doses if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxazosin
- Alfuzosin + Doxazosin Major
- Amifostine + Doxazosin Major
- Avanafil + Doxazosin Major
- Doxazosin + Dutasteride-tamsulosin Major
- Doxazosin + Phentolamine Major
- Doxazosin + Prazosin Major
Other interactions of Carvedilol
Frequently asked questions
Can I take Carvedilol with Doxazosin?
MediHelp rates the interaction as moderate. Carvedilol and Doxazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs block alpha-1 receptors, and carvedilol also blocks beta receptors, so combined use can cause marked hypotension. Dizziness, syncope and first-dose orthostatic effects are the main concerns.
How serious is the interaction between Carvedilol and Doxazosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Introduce one agent at a time at low doses and titrate slowly. Monitor orthostatic blood pressure and reduce doses if symptomatic hypotension occurs.
What other medicines interact with Doxazosin?
MediHelp also lists interactions of Doxazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Doxazosin page.
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