Drug interactions
Carvedilol + Elvitegravir / cobicistat / emtricitabine / tenofovir df
Severity: Moderate
Carvedilol and Elvitegravir / cobicistat / emtricitabine / tenofovir df: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat inhibits CYP2D6 and P-gp and may raise carvedilol concentrations, causing bradycardia and hypotension. Elvitegravir's weak inducing effect is unlikely to offset this.
What this interaction means in plain words
Carvedilol and Elvitegravir / cobicistat / emtricitabine / tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cobicistat inhibits CYP2D6 and P-gp, reducing carvedilol clearance.
What to do
Monitor heart rate and blood pressure and consider lower carvedilol doses. Adjust according to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carvedilol
Frequently asked questions
Can I take Carvedilol with Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates the interaction as moderate. Carvedilol and Elvitegravir / cobicistat / emtricitabine / tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobicistat inhibits CYP2D6 and P-gp and may raise carvedilol concentrations, causing bradycardia and hypotension. Elvitegravir's weak inducing effect is unlikely to offset this.
How serious is the interaction between Carvedilol and Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure and consider lower carvedilol doses. Adjust according to response.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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