Drug interactions
Carvedilol + Fenbufen
Severity: Moderate
Carvedilol and Fenbufen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenbufen is an NSAID, and NSAIDs can blunt the antihypertensive effect of beta-blockers through inhibition of vasodilatory prostaglandins and sodium and fluid retention. Blood pressure control may worsen with regular use. NSAIDs can also raise potassium and impair renal function, particularly in vulnerable patients.
What this interaction means in plain words
Carvedilol and Fenbufen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of prostaglandin synthesis causes sodium and water retention and reduces the vasodilatory effect of carvedilol.
What to do
Monitor blood pressure if fenbufen is used for more than a few days. Use the lowest effective NSAID dose for the shortest time, or choose paracetamol where appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carvedilol
Frequently asked questions
Can I take Carvedilol with Fenbufen?
MediHelp rates the interaction as moderate. Carvedilol and Fenbufen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenbufen is an NSAID, and NSAIDs can blunt the antihypertensive effect of beta-blockers through inhibition of vasodilatory prostaglandins and sodium and fluid retention. Blood pressure control may worsen with regular use. NSAIDs can also raise potassium and impair renal function, particularly in vulnerable patients.
How serious is the interaction between Carvedilol and Fenbufen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure if fenbufen is used for more than a few days. Use the lowest effective NSAID dose for the shortest time, or choose paracetamol where appropriate.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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