Drug interactions
Carvedilol + Glecaprevir / pibrentasvir
Severity: Moderate
Carvedilol and Glecaprevir / pibrentasvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir inhibit P-glycoprotein, so carvedilol exposure may rise and cause bradycardia or hypotension. Carvedilol is also a P-gp inhibitor, but the effect on the antivirals is probably small.
What this interaction means in plain words
Carvedilol and Glecaprevir / pibrentasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Glecaprevir/pibrentasvir inhibit P-gp efflux of carvedilol, and carvedilol may weakly inhibit P-gp.
What to do
Monitor heart rate and blood pressure during the antiviral course. Reduce the carvedilol dose if symptomatic bradycardia or hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carvedilol
Frequently asked questions
Can I take Carvedilol with Glecaprevir / pibrentasvir?
MediHelp rates the interaction as moderate. Carvedilol and Glecaprevir / pibrentasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glecaprevir and pibrentasvir inhibit P-glycoprotein, so carvedilol exposure may rise and cause bradycardia or hypotension. Carvedilol is also a P-gp inhibitor, but the effect on the antivirals is probably small.
How serious is the interaction between Carvedilol and Glecaprevir / pibrentasvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure during the antiviral course. Reduce the carvedilol dose if symptomatic bradycardia or hypotension occurs.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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