Drug interactions
Carvedilol + Hydrochlorothiazide-olmesartan
Severity: Minor
Carvedilol and Hydrochlorothiazide-olmesartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carvedilol has alpha- and beta-blocking properties and lowers blood pressure additively with olmesartan and hydrochlorothiazide, potentially causing orthostatic hypotension or bradycardia. Thiazides may also worsen glycemic control in patients with diabetes.
What this interaction means in plain words
Carvedilol and Hydrochlorothiazide-olmesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carvedilol belongs to Cardiovascular; Hydrochlorothiazide-olmesartan belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects of alpha/beta blockade, angiotensin receptor blockade and diuresis.
What to do
Monitor blood pressure and heart rate, and counsel patients on orthostatic symptoms. Adjust doses if hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Carvedilol
Frequently asked questions
Can I take Carvedilol with Hydrochlorothiazide-olmesartan?
MediHelp rates the interaction as minor. Carvedilol and Hydrochlorothiazide-olmesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Carvedilol has alpha- and beta-blocking properties and lowers blood pressure additively with olmesartan and hydrochlorothiazide, potentially causing orthostatic hypotension or bradycardia. Thiazides may also worsen glycemic control in patients with diabetes.
How serious is the interaction between Carvedilol and Hydrochlorothiazide-olmesartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, and counsel patients on orthostatic symptoms. Adjust doses if hypotension occurs.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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