Drug interactions
Carvedilol + Iobenguane i
Severity: Major
Carvedilol and Iobenguane i: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carvedilol (a combined alpha/beta-blocker) can interfere with the uptake of iobenguane into adrenergic tissue, potentially lowering the diagnostic or therapeutic effectiveness of iobenguane I-131. Labetalol has been specifically linked to this interference, and the concern extends to related agents.
What this interaction means in plain words
Carvedilol and Iobenguane i can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Interference with norepinephrine transporter-mediated uptake of iobenguane into tumor cells.
What to do
Stop carvedilol for at least 5 half-lives before the dosimetry or therapeutic iobenguane dose and do not restart until at least 7 days after each dose, switching to a non-interfering antihypertensive during this time.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Carvedilol
Frequently asked questions
Can I take Carvedilol with Iobenguane i?
MediHelp rates the interaction as major. Carvedilol and Iobenguane i can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carvedilol (a combined alpha/beta-blocker) can interfere with the uptake of iobenguane into adrenergic tissue, potentially lowering the diagnostic or therapeutic effectiveness of iobenguane I-131. Labetalol has been specifically linked to this interference, and the concern extends to related agents.
How serious is the interaction between Carvedilol and Iobenguane i?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop carvedilol for at least 5 half-lives before the dosimetry or therapeutic iobenguane dose and do not restart until at least 7 days after each dose, switching to a non-interfering antihypertensive during this time.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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