Drug interactions
Carvedilol + Lumacaftor / ivacaftor
Severity: Minor
Carvedilol and Lumacaftor / ivacaftor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumacaftor induces and ivacaftor may inhibit CYP2C9, so the net effect on carvedilol is uncertain. CYP2C9 is a minor route for carvedilol, so any effect is probably small. Lumacaftor may also affect P-gp and reduce carvedilol exposure.
What this interaction means in plain words
Carvedilol and Lumacaftor / ivacaftor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing effects on CYP2C9 and transporters, with a net effect that is not established.
What to do
No routine dose change is needed. Monitor heart rate and blood pressure, and adjust carvedilol if the response changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Carvedilol
Frequently asked questions
Can I take Carvedilol with Lumacaftor / ivacaftor?
MediHelp rates the interaction as minor. Carvedilol and Lumacaftor / ivacaftor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lumacaftor induces and ivacaftor may inhibit CYP2C9, so the net effect on carvedilol is uncertain. CYP2C9 is a minor route for carvedilol, so any effect is probably small. Lumacaftor may also affect P-gp and reduce carvedilol exposure.
How serious is the interaction between Carvedilol and Lumacaftor / ivacaftor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor heart rate and blood pressure, and adjust carvedilol if the response changes.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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