Drug interactions
Carvedilol + Lumefantrine
Severity: Moderate
Carvedilol and Lumefantrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine inhibits CYP2D6 and may raise carvedilol concentrations, increasing the risk of hypotension and bradycardia.
What this interaction means in plain words
Carvedilol and Lumefantrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP2D6-mediated carvedilol metabolism.
What to do
Monitor heart rate and blood pressure during the antimalarial course. Reduce the carvedilol dose if symptoms of excess beta-blockade appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carvedilol
Frequently asked questions
Can I take Carvedilol with Lumefantrine?
MediHelp rates the interaction as moderate. Carvedilol and Lumefantrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumefantrine inhibits CYP2D6 and may raise carvedilol concentrations, increasing the risk of hypotension and bradycardia.
How serious is the interaction between Carvedilol and Lumefantrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure during the antimalarial course. Reduce the carvedilol dose if symptoms of excess beta-blockade appear.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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