Drug interactions
Carvedilol + Marijuana
Severity: Moderate
Carvedilol and Marijuana: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabis constituents, notably cannabidiol, inhibit CYP2D6 in vitro, which could increase carvedilol levels. Cannabis can also cause tachycardia, postural hypotension and dizziness, making the net hemodynamic effect unpredictable.
What this interaction means in plain words
Carvedilol and Marijuana can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cannabinoids may inhibit CYP2D6 metabolism of carvedilol and cause additive hemodynamic effects.
What to do
Counsel patients about dizziness and falls. Monitor heart rate and blood pressure in regular cannabis users and adjust carvedilol if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carvedilol
Frequently asked questions
Can I take Carvedilol with Marijuana?
MediHelp rates the interaction as moderate. Carvedilol and Marijuana can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabis constituents, notably cannabidiol, inhibit CYP2D6 in vitro, which could increase carvedilol levels. Cannabis can also cause tachycardia, postural hypotension and dizziness, making the net hemodynamic effect unpredictable.
How serious is the interaction between Carvedilol and Marijuana?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about dizziness and falls. Monitor heart rate and blood pressure in regular cannabis users and adjust carvedilol if needed.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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