Drug interactions
Carvedilol + Meclofenamate
Severity: Moderate
Carvedilol and Meclofenamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclofenamate, an NSAID, can reduce the blood pressure lowering effect of carvedilol with regular use. NSAIDs can also cause fluid retention, worsen heart failure, and raise potassium or impair renal function.
What this interaction means in plain words
Carvedilol and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal and vascular prostaglandin synthesis causes sodium retention and opposes carvedilol's vasodilation.
What to do
Monitor blood pressure, weight and renal function with prolonged use. Use the lowest NSAID dose for the shortest time, and avoid in heart failure when possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Carvedilol and Meclofenamate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Carvedilol
Frequently asked questions
Can I take Carvedilol with Meclofenamate?
MediHelp rates the interaction as moderate. Carvedilol and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meclofenamate, an NSAID, can reduce the blood pressure lowering effect of carvedilol with regular use. NSAIDs can also cause fluid retention, worsen heart failure, and raise potassium or impair renal function.
How serious is the interaction between Carvedilol and Meclofenamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, weight and renal function with prolonged use. Use the lowest NSAID dose for the shortest time, and avoid in heart failure when possible.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
