Drug interactions
Carvedilol + Miconazole vaginal
Severity: Minor
Carvedilol and Miconazole vaginal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vaginal miconazole is systemically absorbed to a small extent and can inhibit CYP2C9, which is a minor route of carvedilol metabolism. Clinically important changes in carvedilol exposure are unlikely.
What this interaction means in plain words
Carvedilol and Miconazole vaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Small systemic miconazole exposure may weakly inhibit CYP2C9 metabolism of carvedilol.
What to do
No dose adjustment is usually needed. Monitor heart rate and blood pressure if prolonged or repeated courses are used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Carvedilol
Frequently asked questions
Can I take Carvedilol with Miconazole vaginal?
MediHelp rates the interaction as minor. Carvedilol and Miconazole vaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vaginal miconazole is systemically absorbed to a small extent and can inhibit CYP2C9, which is a minor route of carvedilol metabolism. Clinically important changes in carvedilol exposure are unlikely.
How serious is the interaction between Carvedilol and Miconazole vaginal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed. Monitor heart rate and blood pressure if prolonged or repeated courses are used.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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