Drug interactions
Carvedilol + Olodaterol inhaled
Severity: Major
Carvedilol and Olodaterol inhaled: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carvedilol is a non-selective beta-blocker that blocks the beta-2 receptors targeted by olodaterol, so the bronchodilator effect may be reduced. In patients with COPD or asthma, beta-2 blockade can also provoke bronchospasm.
What this interaction means in plain words
Carvedilol and Olodaterol inhaled can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Pharmacodynamic antagonism at beta-2 adrenergic receptors by a non-selective beta-blocker.
What to do
Avoid non-selective beta-blockers such as carvedilol in patients needing olodaterol where possible; if a beta-blocker is essential, prefer a cardioselective agent and monitor respiratory function and symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Carvedilol
Frequently asked questions
Can I take Carvedilol with Olodaterol inhaled?
MediHelp rates the interaction as major. Carvedilol and Olodaterol inhaled can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carvedilol is a non-selective beta-blocker that blocks the beta-2 receptors targeted by olodaterol, so the bronchodilator effect may be reduced. In patients with COPD or asthma, beta-2 blockade can also provoke bronchospasm.
How serious is the interaction between Carvedilol and Olodaterol inhaled?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid non-selective beta-blockers such as carvedilol in patients needing olodaterol where possible; if a beta-blocker is essential, prefer a cardioselective agent and monitor respiratory function and symptoms.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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