Drug interactions
Carvedilol + Pentobarbital
Severity: Moderate
Carvedilol and Pentobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentobarbital induces hepatic drug-metabolizing enzymes and may lower carvedilol plasma concentrations. The beta-blocking and antihypertensive effect may be reduced, while additive sedation or hypotension can also occur.
What this interaction means in plain words
Carvedilol and Pentobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturate induction of hepatic CYP enzymes increases the metabolism of carvedilol.
What to do
Monitor heart rate and blood pressure and increase the carvedilol dose if response is lost; reassess when the barbiturate is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carvedilol
Frequently asked questions
Can I take Carvedilol with Pentobarbital?
MediHelp rates the interaction as moderate. Carvedilol and Pentobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pentobarbital induces hepatic drug-metabolizing enzymes and may lower carvedilol plasma concentrations. The beta-blocking and antihypertensive effect may be reduced, while additive sedation or hypotension can also occur.
How serious is the interaction between Carvedilol and Pentobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure and increase the carvedilol dose if response is lost; reassess when the barbiturate is stopped.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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