Drug interactions
Carvedilol + Pindolol
Severity: Moderate
Carvedilol and Pindolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are beta-blockers, so combining them duplicates therapy with additive bradycardia and hypotension. Pindolol's partial agonist activity may also partially counter carvedilol's effect.
What this interaction means in plain words
Carvedilol and Pindolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive beta-blockade, with pindolol's intrinsic sympathomimetic activity partially opposing carvedilol.
What to do
Avoid duplicate beta-blocker therapy and use one agent. If both are given, monitor heart rate and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carvedilol
Frequently asked questions
Can I take Carvedilol with Pindolol?
MediHelp rates the interaction as moderate. Carvedilol and Pindolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are beta-blockers, so combining them duplicates therapy with additive bradycardia and hypotension. Pindolol's partial agonist activity may also partially counter carvedilol's effect.
How serious is the interaction between Carvedilol and Pindolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicate beta-blocker therapy and use one agent. If both are given, monitor heart rate and blood pressure.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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