Drug interactions
Carvedilol + Quinacrine
Severity: Moderate
Carvedilol and Quinacrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinacrine may inhibit CYP2D6, the main enzyme metabolizing carvedilol, raising its concentrations. This may increase bradycardia, hypotension and dizziness.
What this interaction means in plain words
Carvedilol and Quinacrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP2D6 inhibition reduces carvedilol metabolism.
What to do
Monitor heart rate and blood pressure and lower the carvedilol dose if excessive beta-blockade occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carvedilol
Frequently asked questions
Can I take Carvedilol with Quinacrine?
MediHelp rates the interaction as moderate. Carvedilol and Quinacrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinacrine may inhibit CYP2D6, the main enzyme metabolizing carvedilol, raising its concentrations. This may increase bradycardia, hypotension and dizziness.
How serious is the interaction between Carvedilol and Quinacrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure and lower the carvedilol dose if excessive beta-blockade occurs.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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