Drug interactions
Carvedilol + Rifampin
Severity: Moderate
Carvedilol and Rifampin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin induces metabolic enzymes and P-glycoprotein, and substantially lowers carvedilol plasma concentrations. This can lead to loss of blood pressure, angina or heart failure control.
What this interaction means in plain words
Carvedilol and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of hepatic CYP enzymes and intestinal P-glycoprotein increases carvedilol clearance and reduces absorption.
What to do
Monitor blood pressure and heart rate and raise the carvedilol dose if needed; reduce again after rifampin is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carvedilol
Frequently asked questions
Can I take Carvedilol with Rifampin?
MediHelp rates the interaction as moderate. Carvedilol and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampin induces metabolic enzymes and P-glycoprotein, and substantially lowers carvedilol plasma concentrations. This can lead to loss of blood pressure, angina or heart failure control.
How serious is the interaction between Carvedilol and Rifampin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and raise the carvedilol dose if needed; reduce again after rifampin is stopped.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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