Drug interactions
Carvedilol + Sacubitril / valsartan
Severity: Moderate
Carvedilol and Sacubitril / valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The combination is commonly used in heart failure, but both agents lower blood pressure and hypotension or dizziness may occur, especially at initiation. Hyperkalemia and renal effects are driven by valsartan rather than carvedilol.
What this interaction means in plain words
Carvedilol and Sacubitril / valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic blood pressure lowering from beta-blockade and angiotensin receptor blockade with neprilysin inhibition.
What to do
Monitor blood pressure, heart rate, potassium and renal function when initiating or titrating, and adjust doses for symptomatic hypotension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Carvedilol and Sacubitril / valsartan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Carvedilol
Frequently asked questions
Can I take Carvedilol with Sacubitril / valsartan?
MediHelp rates the interaction as moderate. Carvedilol and Sacubitril / valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The combination is commonly used in heart failure, but both agents lower blood pressure and hypotension or dizziness may occur, especially at initiation. Hyperkalemia and renal effects are driven by valsartan rather than carvedilol.
How serious is the interaction between Carvedilol and Sacubitril / valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate, potassium and renal function when initiating or titrating, and adjust doses for symptomatic hypotension.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
