Drug interactions
Carvedilol + Salsalate
Severity: Moderate
Carvedilol and Salsalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate is a salicylate NSAID that may reduce the blood pressure lowering effect of carvedilol with continued use. Fluid retention and renal impairment may be relevant in heart failure patients.
What this interaction means in plain words
Carvedilol and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Prostaglandin synthesis inhibition leads to sodium retention and antagonizes antihypertensive effect.
What to do
Monitor blood pressure and signs of fluid retention, and limit the salsalate dose and duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carvedilol
Frequently asked questions
Can I take Carvedilol with Salsalate?
MediHelp rates the interaction as moderate. Carvedilol and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate is a salicylate NSAID that may reduce the blood pressure lowering effect of carvedilol with continued use. Fluid retention and renal impairment may be relevant in heart failure patients.
How serious is the interaction between Carvedilol and Salsalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and signs of fluid retention, and limit the salsalate dose and duration.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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