Drug interactions
Carvedilol + Sildenafil
Severity: Moderate
Carvedilol and Sildenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carvedilol has alpha-1 blocking and vasodilating activity in addition to beta blockade, and sildenafil adds further vasodilation. The combination can cause orthostatic or symptomatic hypotension.
What this interaction means in plain words
Carvedilol and Sildenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Sildenafil belongs to Genitourinary.
Why it happens
Additive vasodilation from PDE5 inhibition and alpha-1/beta adrenergic blockade.
What to do
Use the lowest sildenafil dose initially and ensure the patient is stable on carvedilol. Monitor blood pressure and counsel about postural dizziness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sildenafil
- Amyl nitrite + Sildenafil Contraindicated
- Atazanavir + Sildenafil Contraindicated
- Cobicistat + Sildenafil Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Sildenafil Contraindicated
- Glyceryl trinitrate pr + Sildenafil Contraindicated
- Isosorbide dinitrate + Sildenafil Contraindicated
Other interactions of Carvedilol
Frequently asked questions
Can I take Carvedilol with Sildenafil?
MediHelp rates the interaction as moderate. Carvedilol and Sildenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carvedilol has alpha-1 blocking and vasodilating activity in addition to beta blockade, and sildenafil adds further vasodilation. The combination can cause orthostatic or symptomatic hypotension.
How serious is the interaction between Carvedilol and Sildenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest sildenafil dose initially and ensure the patient is stable on carvedilol. Monitor blood pressure and counsel about postural dizziness.
What other medicines interact with Sildenafil?
MediHelp also lists interactions of Sildenafil with, for example, Amyl nitrite, Atazanavir, Cobicistat. The full list is on the Sildenafil page.
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