Drug interactions
Carvedilol + Sulfamethoxazole
Severity: Minor
Carvedilol and Sulfamethoxazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfamethoxazole inhibits CYP2C9, which participates in carvedilol metabolism, so carvedilol levels may increase slightly. The clinical effect is expected to be small.
What this interaction means in plain words
Carvedilol and Sulfamethoxazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
CYP2C9 inhibition modestly reduces carvedilol clearance.
What to do
No dose change is usually needed; monitor heart rate and blood pressure.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Carvedilol
Frequently asked questions
Can I take Carvedilol with Sulfamethoxazole?
MediHelp rates the interaction as minor. Carvedilol and Sulfamethoxazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sulfamethoxazole inhibits CYP2C9, which participates in carvedilol metabolism, so carvedilol levels may increase slightly. The clinical effect is expected to be small.
How serious is the interaction between Carvedilol and Sulfamethoxazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor heart rate and blood pressure.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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