Drug interactions
Carvedilol + Umeclidinium bromide / vilanterol inhaled
Severity: Major
Carvedilol and Umeclidinium bromide / vilanterol inhaled: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carvedilol is a nonselective beta-blocker and can block the bronchodilating effect of vilanterol. In patients with COPD or asthma this may cause bronchospasm and loss of symptom control.
What this interaction means in plain words
Carvedilol and Umeclidinium bromide / vilanterol inhaled can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Pharmacodynamic antagonism at beta-2 adrenoceptors by nonselective beta-blockade of the inhaled beta-2 agonist.
What to do
Avoid carvedilol in patients with obstructive airway disease where possible and use a cardioselective beta-blocker such as bisoprolol if needed. Monitor respiratory symptoms and lung function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Carvedilol
Frequently asked questions
Can I take Carvedilol with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as major. Carvedilol and Umeclidinium bromide / vilanterol inhaled can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carvedilol is a nonselective beta-blocker and can block the bronchodilating effect of vilanterol. In patients with COPD or asthma this may cause bronchospasm and loss of symptom control.
How serious is the interaction between Carvedilol and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid carvedilol in patients with obstructive airway disease where possible and use a cardioselective beta-blocker such as bisoprolol if needed. Monitor respiratory symptoms and lung function.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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